Alliance of Glycobiologists

Partners

CFG Nature - Functional Glycomics Gateway
Systems Biology Technology Centers
Programs in Excellence in Glycosciences
Early Detection Research Network (EDRN)

Publications

These publications are sorted by topic and by date of publication.


Glycan Structural Analysis

Hirose H, Tamai H, Gao C, Imamura A, Ando H, Ishida H, Feizi T, Kiso M. Total syntheses of disulphated glycosphingolipid SB1a and the related monosulphated SM1a. Org Biomol Chem. 2015 Sep 24. [Epub ahead of print]

Gao C, Liu Y, Zhang H, Zhang Y, Fukuda MN, Palma AS, Kozak RP, Childs RA, Nonaka M, Li Z, Siegel DL, Hanfland P, Peehl DM, Chai W, Greene MI, Feizi T. Carbohydrate sequence of the prostate cancer-associated antigen F77 assigned by a mucin O-glycome designer array. J Biol Chem. 2014; 289(23):16462-16477.

Nonaka M, Fukuda MN, Gao C, Li Z, Zhang H, Greene M, Peehl DM, Feizi T, Fukuda M. Determination of carbohydrate structure recognized by prostate-specific F77 monoclonal antibody through expression analysis of glycosyltransferase genes. J Biol Chem. 2014; 289(23):16478-16486.


Glycan Profile Analysis

Kudelka MR, Antonopoulos A, Wang Y, Duong DM, Song X, Seyfried NT, Dell A, Haslam SM, Cummings RD, Ju T. Cellular O-Glycome Reporter/Amplification to explore O-glycans of living cells. Nat Methods 2016 Jan;13(1):81-6.

Allam H, Aoki K, Benigno BB, McDonald JF, Mackintosh SG, Tiemeyer M, Abbott KL. Glycomic analysis of membrane glycoproteins with bisecting glycosylation from ovarian cancer tissues reveals novel structures and functions. J Proteome Res. 2015; 14(1):434-46.

Powers TW, Neely BA, Shao Y, Tang H, Troyer DA, Mehta AS, Haab BB, Drake RR. MALDI imaging mass spectrometry profiling of N-glycans in formalin-fixed paraffin embedded clinical tissue blocks and tissue microarrays. PLoS One. 2014; 9(9):e106255.

Comunale MA, Wang M, Anbarasan N, Betesh L, Karabudak A, Moritz E, Devarajan K, Marrero J, Block TM, Mehta A. Total serum glycan analysis is superior to lectin-FLISA for the early detection of hepatocellular carcinoma. Proteomics Clin Appl. 2013 Jul 16. [Epub ahead of print]

Powers TW, Jones EE, Betesh LR, Romano PR, Gao P, Copland JA, Mehta AS, Drake RR. Matrix assisted laser desorption ionization imaging mass spectrometry workflow for spatial profiling analysis of N-linked glycan expression in tissues. Anal Chem. 2013; 85(20):9799-806.

Nyalwidhe JO, Betesh LR, Powers TW, Jones EE, White KY, Burch TC, Brooks J, Watson MT, Lance RS, Troyer DA, Semmes OJ, Mehta A, Drake RR. Increased bisecting N-acetylglucosamine and decreased branched chain glycans of N-linked glycoproteins in expressed prostatic secretions associated with prostate cancer progression. Proteomics Clin Appl. 2013; Jun 17. [Epub ahead of print]

Svoboda M, Mann B, Goetz JA, Novotny MV. Examination of Glycan Profiles from IgG-Depleted Human Immunoglobulins Facilitated by Microscale Affinity Chromatography. Anal Chem. 2012; 84(7):3269-77.

Alley WR, Vasseur JA, Goetz JA, Svoboda M, Mann BF, Matei DE, Menning N, Hussein A, Mechref Y, Novotny MV. N-linked Glycan Structures and Their Expressions Change in the Blood Sera of Ovarian Cancer Patients. J Proteome Res. 2012; 11(4):2282-300.

Zhuang Z, Mitra I, Hussein A, Novotny MV, Mechref Y, Jacobson S. Microchip Electrophoresis of N-Glycans on Serpentine Separation Channels with Asymmetrically Tapered Turns. Electrophoresis 2011; 32(2):246-53.

Mann B, Madera M, Klouckova I, Dobrolecki LE, Hickey RJ, Hammoud ZT, Novotny MV. A Quantitative Investigation of Fucosylated Serum Glycoproteins with Application to Esophageal Adenocarcinoma. Electrophoresis 2010; 31, 1833-1841.

Alley WR Jr, Madera M, Mechref Y, Novotny MV. Chip-based reversed-phase liquid chromatography-mass spectrometry of permethylated N-linked glycans: a potential methodology for cancer-biomarker discovery. Anal Chem. 2010; 82(12):5095-106.

Alley WR, Novotny MV. Glycomic analysis of sialic acid linkages in glycans derived from blood serum glycoproteins. J Proteome Res. 2010; 9(6): 3062-72.

Mann B, Madera M, Klouckova I, Mechref Y, Dobrolecki LE, Hickey RJ, Hammoud ZT, Novotny MV. A quantitative investigation of fucosylated serum glycoproteins with application to esophageal adenocarcinoma. Electrophoresis. 2010; 31(11):1833-41.

Goetz JA, Mechref Y, Kang P, Jeng MH, Novotny, MV. Glycomic profiling of invasive and non-invasive breast cancer cells. Glycoconj J. 2009; 26(2):117-31.

Goldman R, Ressom HW, Varghese RS, Goldman L, Bascug G, Loffredo CA, Abdel-Hamid M, Gouda I, Ezzat S, Kyselova Z, Mechref Y, Novotny M.V. Detection of hepatocellular carcinoma using glycomic analysis. Clinical Cancer Res. 2009; 15(5):1808-13.

Mechref Y, Hussein A, Bekesova S, Pungpapong V, Zhang M, Dobrolecki LE, Hickey RJ, Hammoud ZT, Novotny MV. Quantitative serum glycomics of esophageal adenocarcinoma and other esophageal disease onsets. J Proteome Res. 2009; 8(6):2656-66.

Isailovic D, Kurulugama RT, Plasencia MD, Stokes ST, Kyselova Z, Goldman R, Mechref Y, Novotny MV, Clemmer DE. Profiling of human serum glycans associated with liver cancer and cirrhosis by IMS-MS. J Proteome Res. 2008; 7:1109-1117.

Kyselova Z, Mechref Y, Kang P, Goetz JA, Dobrolecki LE, Sledge GW, Schnaper L, Hickey RJ, Malkas LH, Novotny, MV. Breast cancer diagnosis and prognosis through quantitative measurements of serum glycan profiles. Clin Chem. 2008; 54:1166-1175.

Ressom HW, Varghese RS, Goldman L, An Y, Loffredo CA, Abdel-Hamid M, Kyselova Z, Mechref Y, Novotny M, Drake SK, Goldman R. Analysis of MALDI-TOF mass spectrometry data for discovery of peptide and glycan biomarkers of hepatocellular carcinoma. J Proteome Res. 2008; 7:603-610.

Kyselova Z, Mechref Y, Al Bataineh M, Dobrolecki L E, Hickey RJ, Sweeney CJ, Novotny MV. Alterations in the serum glycome due to metastatic prostate cancer. J Proteome Res. 2007; 6:1822-1832.

Zhuang Z, Starkey JA, Mechref Y, Novotny MV, Jacobson SC. Electrophoretic analysis of n-glycans on microfluidic devices. Anal Chem. 2007; 79:7170-7175.

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Glycoproteomics

Darebna P, Novak P, Kucera R, Topolcan O, Sanda M, Goldman R, Pompach P. Changes in the expression of N- and O-glycopeptides in patients with colorectal cancer and hepatocellular carcinoma quantified by full-MS scan FT-ICR and multiple reaction monitoring. J Proteomics 2017 Feb 5;153:44-52. doi: 10.1016/j.jprot.2016.09.004.

Sanda M, Zhang L, Edwards NJ, Goldman R. Site-specific analysis of changes in the glycosylation of proteins in liver cirrhosis using data-independent workflow with soft fragmentation. Anal Bioanal Chem 2017 Jan;409(2):619-627. doi: 10.1007/s00216-016-0041-8.

Heijs B, Holst S, Briaire-de Bruijn IH, van Pelt GW, de Ru AH, van Veelen PA, Drake RR, Mehta AS, Mesker WE, Tollenaar RA, Bovée JV, Wuhrer M, McDonnell LA. Multimodal Mass Spectrometry Imaging of N-Glycans and Proteins from the Same Tissue Section. Anal Chem 2016 Aug 2;88(15):7745-53. doi: 10.1021/acs.analchem.6b01739.

Holst S, Heijs B, de Haan N, van Zeijl RJ, Briaire-de Bruijn IH, van Pelt GW, Mehta AS, Angel PM, Mesker WE, Tollenaar RA, Drake RR, Bovée JV, McDonnell LA, Wuhrer M. Linkage-Specific in Situ Sialic Acid Derivatization for N-Glycan Mass Spectrometry Imaging of Formalin-Fixed Paraffin-Embedded Tissues. Anal Chem 2016 Jun 7;88(11):5904-13. doi: 10.1021/acs.analchem.6b00819.

Sanda M, Benicky J, Wu J, Wang Y, Makambi K, Ahn J, Smith CI, Zhao P, Zhang L, Goldman R. Increased sialylation of site specific O-glycoforms of hemopexin in liver disease. Clin Proteomics 2016 Sep 21;13:24. doi: 10.1186/s12014-016-9125-x.

Sanda M, Goldman R. Data Independent Analysis of IgG Glycoforms in Samples of Unfractionated Human Plasma. Anal Chem 2016 Oct 18;88(20):10118-10125.

Tang H, Partyka K, Hsueh P, Sinha JY, Kletter D, Zeh H, Huang Y, Brand RE, Haab BB. Glycans related to the CA19-9 antigen are elevated in distinct subsets of pancreatic cancers and improve diagnostic accuracy over CA19-9. Cell Mol Gastroenterol Hepatol 2016 Feb 1;2(2):201-221.e15.

Powers TW, Holst S, Wuhrer M, Mehta AS, Drake RR. Two-Dimensional N-Glycan Distribution Mapping of Hepatocellular Carcinoma Tissues by MALDI-Imaging Mass Spectrometry. Biomolecules 2015 Oct 15;5(4):2554-72. doi: 10.3390/biom5042554.

Tang H, Singh S, Partyka K, Kletter D, Hsueh P, Yadav J, Ensink E, Bern M, Hostetter G, Hartman D, Huang Y, Brand RE, Haab BB. Glycan motif profiling reveals plasma sialyl-lewis x elevations in pancreatic cancers that are negative for sialyl-lewis A. Mol Cell Proteomics 2015 May;14(5):1323-33.

Singh S, Pal K, Yadav J, Tang H, Partyka K, Kletter D, Hsueh P, Ensink E, Kc B, Hostetter G, Xu HE, Bern M, Smith DF, Mehta AS, Brand R, Melcher K, Haab BB. Upregulation of glycans containing 3' fucose in a subset of pancreatic cancers uncovered using fusion-tagged lectins. J Proteome Res 2015 Jun 5;14(6):2594-605.

Yuan W, Sanda M, Wu J, Koomen J, Goldman R. Quantitative analysis of immunoglobulin subclasses and subclass specific glycosylation by LC-MS-MRM in liver disease. J Proteomics. 2015;116:24-33.

Goldman R, Sanda M. Targeted methods for quantitative analysis of protein glycosylation. Proteomics Clin Appl. 2015;9(1-2):17-32.

Cole C, Krampis K, Karagiannis K, Almeida JS, Faison WJ, Motwani M, Wan Q, Golikov A, Pan Y, Simonyan V, Mazumder R. Non-synonymous variations in cancer and their effects on the human proteome: workflow for NGS data biocuration and proteome-wide analysis of TCGA data. BMC Bioinformatics 2014 Jan 27;15:28. doi: 10.1186/1471-2105-15-28.

Powers TW, Neely BA, Shao Y, Tang H, Troyer DA, Mehta AS, Haab BB, Drake RR. MALDI imaging mass spectrometry profiling of N-glycans in formalin-fixed paraffin embedded clinical tissue blocks and tissue microarrays. PLoS One 2014 Sep 3;9(9):e106255. doi: 10.1371/journal.pone.0106255.

Pompach P, Ashline DJ, Brnakova Z, Benicky J, Sanda M, Goldman R. Protein and site specificity of fucosylation in liver-secreted glycoproteins. J Proteome Res. 2014; 13(12):5561-9.

Benicky J, Sanda M, Pompach P, Wu J, Goldman R. Quantification of fucosylated hemopexin and complement factor H in plasma of patients with liver disease. Anal Chem. 2014; 86(21):10716-23.

Nayak A, Pattabiraman N, Fadra N, Goldman R, Kosakovsky Pond SL, Mazumder R. Structure-function analysis of hepatitis C virus envelope glycoproteins E1 and E2. J Biomol Struct Dyn. 2014; 15:1-13.

Chandler KB, Brnakova Z, Sanda M, Wang S, Stalnaker SH, Bridger R, Zhao P, Wells L, Edwards NJ, Goldman R. Site-specific glycan microheterogeneity of inter-alpha-trypsin inhibitor heavy chain H4. J Proteome Res. 2014; 13(7):3314-29.

Porterfield M, Zhao P, Han H, Cunningham J, Aoki K, Von Hoff DD, Demeure MJ, Pierce JM, Tiemeyer M, Wells L. Discrimination between Adenocarcinoma and normal pancreatic ductal fluid by proteomic and glycomic analysis. J Proteome Res. 2014; 13(2):395-407.

Karagiannis K, Simonyan V, Mazumder R. SNVDis: a proteome-wide analysis service for evaluating nsSNVs in protein functional sites and pathways. Genomics Proteomics Bioinformatics 2013 Apr;11(2):122-6. doi: 10.1016/j.gpb.2012.10.003.

Powers TW, Jones EE, Betesh LR, Romano PR, Gao P, Copland JA, Mehta AS, Drake RR. Matrix assisted laser desorption ionization imaging mass spectrometry workflow for spatial profiling analysis of N-linked glycan expression in tissues. Anal Chem 2013 Oct 15;85(20):9799-806. doi: 10.1021/ac402108x.

Chandler KB, Pompach P, Goldman R, Edwards N. Exploring site-specific N-glycosylation microheterogeneity of haptoglobin using glycopeptide CID tandem mass spectra and glycan database search. J Proteome Res. 2013; 12(8):3652-66.

Sanda M, Pompach P, Benicky J, Goldman R. LC-MS3 quantification of O-glycopeptides in human serum. Electrophoresis. 2013; 34(16):2342-9.

Lam PV, Goldman R, Karagiannis K, Narsule T, Simonyan V, Soika V, Mazumder R. Structure-based Comparative Analysis and Prediction of N-linked Glycosylation Sites in Evolutionarily Distant Eukaryotes. Genomics Proteomics Bioinformatics. 2013; 1:96-104.

Pompach P, Brnakova Z, Sanda M, Wu J, Edwards N, Goldman R. Site specific glycoforms of haptoglobin in liver cirrhosis and hepatocellular carcinoma. Mol Cell Proteomics. 2013; 12:1281-93.

Sanda M, Pompach P, Brnakova Z, Wu J, Makambi K, Goldman R. Quantitative LC-MS-MRM analysis of site-specific glycoforms of haptoglobin in liver disease. Mol Cell Proteomics. 2013; 12:1294-305.

Wu SL, Taylor AD, Lu Q, Hanash SM, Im H, Snyder M, Hancock WS. Identification of potential glycan cancer markers with sialic acid attached to sialic acid and up-regulated fucosylated galactose structures in epidermal growth factor receptor secreted from A431 cell line. Mol Cell Proteomics. 2013 Jan 31. [Epub ahead of print]

Zhao P, Nairn AV, Hester S, Moremen KW, O'Regan RM, Oprea G, Wells L, Pierce M, Abbott KL. Proteomic identification of glycosylphosphatidylinositol anchor-dependent membrane proteins elevated in breast carcinoma. J Biol Chem. 2012; 287(30):25230-40.

Mann BF, Goetz JA, House MG, Schmidt CM, Novotny MV. Glycomic and proteomic profiling of pancreatic cyst fluids identifies hyperfucosylated lactosamines on the N-linked glycans of overexpressed glycoproteins. Mol Cell Proteomics. 2012; 11(7):M111.015792.

Liang H, Block TM, Wang M, Nefsky B, Long R, Hafner J, Mehta AS, Marrero J, Gish R, Norton PA. Interleukin-6 and oncostatin M are elevated in liver disease in conjunction with candidate hepatocellular carcinoma biomarker GP73. Cancer Biomark. 2012; 11(4):161-71.

Paik YK, Jeong SK, Omenn GS, Uhlen M, Hanash S, Cho SY, et al. A Chromosome-Centric Human Proteome Project to Characterize the Sets of Proteins Encoded in the Genome Nature Biotech., 2012; 30(3):221-3.

Rafalko A, Dai S, Hancock WS, Karger BL, Hincapie M. Development of a Chip/Chip/SRM Platform Using Digital Chip Isoelectric Focusing and LC-Chip Mass Spectrometry for Enrichment and Quantitation of Low Abundance Protein Biomarkers in Human Plasma. J Proteome Res. 2012; 11:808-17.

Tep S, Hincapie M, Hancock WS. A general approach for the purification and quantitative glycomic analysis of human plasma. Anal Bioanal Chem. 2012; 402:2687-700.

Zeng Z, Hincapie M, Haab BB, Hanash S, Pitteri SJ, Kluck S, Hogan JM, Kennedy J, Hancock WS. The development of an integrated platform to identify breast cancer glycoproteome changes in human serum. J Chromatogr A. 2010 May 7; 1217(19):3307-15.

Abbott KL, Lim JM, Wells L, Benigno BB, McDonald JF, Pierce M. Identification of candidate biomarkers with cancer-specific glycosylation in the tissue and serum of endometrioid ovarian cancer patients by glycoproteomic analysis. Proteomics. 2010; 10(3): 470-81.

No publications on this topic were published during this year.

Abbott KL, Aoki K, Lim JM, Porterfield M, Johnson R, O'Regan RM, Wells L, Tiemeyer M, Pierce M. Targeted glycoproteomic identification of biomarkers for human breast carcinoma. J Proteome Res. 2008; 7(4):1470-80.

No publications on this topic were published during this year.

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Glycan/Glycopeptide Array Technologies

Wang D, Bhat R, Sobel RA, Huang W, Wang L-X, Olsson T, Steinman L Uncovering Cryptic Glycan Markers in Multiple Sclerosis (MS) and Experimental Autoimmune Encephalomyelitis (EAE) Drug Dev Res. 2014 Mar 11.

Kletter D, Singh S, Bern M, Haab BB. Global comparisons of lectin-glycan interactions using a database of analyzed glycan array data. Mol Cell Proteomics. 2013 Feb 11. [Epub ahead of print]

Wang D, Dafik L, Nolley R, Huang W, Wolfinger RD, Wang L-X, Peehl DM Anti-oligomannose antibodies as potential serum biomarkers of aggressive prostate cancer. Drug Dev Res. 2013 Feb 11.

Padler-Karavani V, Song X, Yu H, Hurtado-Ziola N, Huang S, Muthana S, Chokhawala HA, Cheng J, Verhagen A, Langereis MA, Kleene R, Schachner M, de Groot RJ, Lasanajak Y, Matsuda H, Schwab R, Chen X, Smith DF, Cummings RD, Varki A. Cross-comparison of protein recognition of sialic acid diversity on two novel sialoglycan microarrays. J Biol Chem. 2012; 287(27):22593-608.

Bovin NV, Obukhova P, Shilova N, Rapoport E, Popova I, Navakouski M, Unverzagt C, Vuskovic M, Huflejt M. Repertoire of human natural anti-glycan immunoglobulins. Do we have auto-antibodies? Biochim Biophys Acta. 2012; 1820(9):1373-82.

Vuskovic MI, Fang H, Pass HI, Huflejt ME. Optimal combination of glycan-based serum diagnostic markers which maximize AUC. J Systemics Cybernetics Informatics. 2012; (In Press).

Zhou X, Zhang J, Wang D. Microwave-assisted method for fabrication of carbohydrate cluster microarrays on 3-dimensional hydrazide-dendrimer substrate. Methods Mol Biol. 2012; 808:401-11.

Jacob F, Goldstein DR, Bovin NV, Pochechueva T, Spengler M, Caduff R, Fink D, Vuskovic MI, Huflejt ME, Heinzelmann-Schwarz V. Serum anti-glycan antibody detection of non-mucinous ovarian cancers by using a printed glycan array. Int J Cancer. 2012; 130:138-46.

Pochechueva T, Jacob F, Goldstein DR, Huflejt ME, Chinarev A, Caduff R, Fink D, Hacker N, Bovin NV, Heinzelmann-Schwarz V. Comparison of printed glycan array, suspension array and ELISA in the detection of human anti-glycan antibodies. Glycoconj J. 2011; 28:507-17.

Vuskovic MI, Xu H, Bovin NV, Pass HI, Huflejt ME. Processing and analysis of serum antibody binding signals from Printed Glycan Arrays for diagnostic and prognostic applications. Int J Bioinf Res App. 2011; 7: 402-426.

Palma AS, Liu Y, Childs RA, Herbert C, Wang D, Chai W, Feizi T. The human epithelial carcinoma antigen recognized by monoclonal antibody AE3 is expressed on a sulfoglycolipid in addition to neoplastic mucins. Biochem Biophys Res Commun. 2011; 408:548-52.

Blixt O, Bueti D, Burford B, Allen D, Julien S, Hollingsworth M, Gammerman A, Fentiman I, Taylor-Papadimitriou J, Burchell JM. Autoantibodies to aberrantly glycosylated MUC1 in early stage breast cancer are associated with a better prognosis. Breast Cancer Res. 2011; 13(2):R25. [Epub ahead of print]

Kracun SK, Clo E, Clausen H, Levery SB, Jensen KJ, Blixt O. Random glycopeptide bead libraries for seromic biomarker discovery. J Proteome Res. 2010; 9(12):6705-14.

Blixt O, Clo E, Nudelman AS, S?rensen KK, Clausen T, Wandall HH, Livingston PO, Clausen H, Jensen KJ. A high-throughput O-glycopeptide discovery platform for seromic profiling. J Proteome Res. 2010; 9(10):5250-61. Erratum in: J Proteome Res. 2011 10(3):1436.

Dunlop DC, Bonomelli C, Mansab F, Vasiljevic S, Doores KJ, Wormald MR, Palma AS, Feizi T, Harvey DJ, Dwek RA, Crispin M, Scanlan CN. Polysaccharide mimicry of the epitope of the broadly neutralizing anti-HIV antibody, 2G12, induces enhanced antibody responses to self oligomannose glycans. Glycobiology. 2010; 20(7):812-23.

Taylor RE, Gregg CJ, Padler-Karavani V, Ghaderi D, Yu H, Huang S, Sorenson RU, Chen X, Inostroza J, Nizet V, Varki A. Novel mechanism for the generation of human xeno-autoantibodies against the nonhuman sialic acid N-glycolylneuraminic acid. J. Exp. Med. 2010; 207:1637-1646.

Wandall HH, Blixt O, Tarp MA, Pedersen JW, Bennett EP, Mandel U, Ragupathi G, Livingston PO, Hollingsworth MA, Taylor-Papadimitriou J, Burchell J, Clausen H. Cancer biomarkers defined by autoantibody signatures to aberrant O-glycopeptide epitopes. Cancer Res. 2010; 70(4):1306-13.

Carroll GT, Wang D, Turro NJ, Koberstein JT. Photogeneration of carbohydrate microarrays. In: ed. Dill K, Liu R, Grodzinski P. Microarrays: new development towards recognition of bio-signals. Springer, 2009.

Huflejt ME, Vuskovic MI, Vasiliu D, Xu H, Obukhova P, Shilova N, Tuzikov et al. Anti-carbohydrate antibodies of normal sera: findings, surprises and challenges. Mol Immunol. 2009; 46: 3037-3049.

Huang W, Wang D, Yamada M, Wang L. Chemoenzymatic synthesis and lectin array characterization of a class of N-glycan clusters. J Am Chem Soc 2009; 131(49):17963-71.

Zhou X, Turchi C, Wang D. Carbohydrate cluster microarrays fabricated on 3-dimensional dendrimeric platforms for functional glycomics exploration. J Proteome Res. 2009; 8(11): 5031-40.

Carroll GT, Wang D, Turro NJ, Koberstein JT. Photons to illuminate the universe of sugar diversity through bioarrays. Glycoconj J. 2008; 25(1):5-10. Epub 2007 Jul 4.

Shilova NV, Galanina OE, Rubina AY, Butvilovskaya VI, Huflejt ME, Chambers J, Roucoux A, Bovin NV. 2-Aminopyridine—a label for bridging of oligo-saccharides HPLS profiling and glycoarray printing. Glycoconj J. 2008; 25: 11-14.

Wang D, Gedela S. Insights of new tools in glycomics research [editorial]. J Proteomics Bioinform. 2008; 1(8): 374-378.

No publications on this topic were published during this year.

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Glycan Affinity Approaches

Norton P, Comunale MA, Herrera H, Wang M, Houser J, Wimmerova M, Romano PR, Mehta A. Development and application of a novel recombinant Aleuria aurantia lectin with enhanced core fucose binding for identification of glycoprotein biomarkers of hepatocellular carcinoma. Proteomics 2016 Dec;16(24):3126-3136. doi: 10.1002/pmic.201600064.

Wang M, Comunale MA, Herrera H, Betesh L, Kono Y, Mehta A. Identification of IgM as a contaminant in lectin-FLISA assays for HCC detection. Biochem Biophys Res Commun 2016 Jul 29;476(3):140-5. doi: 10.1016/j.bbrc.2016.05.027.

No publications on this topic were published during this year.

Dolezal S, Hester S, Kirby PS, Nairn A, Pierce M, Abbott KL. Elevated levels of glycophosphatidylinositol (GPI) anchored proteins in serum from human cancers detected by C. septicum alpha toxin. Cancer Biomark. 2014; 14(1):55-62.

McCarter C, Kletter D, Tang H, Partyka K, Ma Y, Singh S, Yadav J, Bern M, Haab BB. Prediction of glycan motifs using quantitative analysis of multi-lectin binding: Motifs on MUC1 produced by cultured pancreatic cancer cells. Proteomics Clin Appl. 2013; doi: 10.1002/prca.201300069.

Kletter D, Cao Z, Bern M, Haab B. Determining lectin specificity from glycan array data using motif segregation and GlycoSearch software. Curr Protoc Chem Biol. 2013; 5(2):157-69. doi: 10.1002/9780470559277.ch130028.

Lamontagne A, Long RE, Comunale MA, Hafner J, Rodemich-Betesh L, Wang M, Marrero J, Di Bisceglie AM, Block T, Mehta A. Altered functionality of anti-bacterial antibodies in patients with chronic hepatitis C virus infection. PLoS One. 2013 Jun 4;8(6):e64992.

Cao Z, Partyka K, McDonald M, Brouhard E, Hincapie M, Brand RE, Hancock WS, Haab BB. Modulation of glycan detection on specific glycoproteins by lectin multimerization. Anal Chem. 2013; 85(3):1689-98.

Pejchal R, Doores KJ, Walker LM, Khayat R, Huang PS, Wang SK, Stanfield RL, Julien JP, Ramos A, Crispin M, Depetris R, Katpally U, Marozsan A, Cupo A, Maloveste S, Liu Y, McBride R, Ito Y, Sanders RW, Ogohara C, Paulson JC, Feizi T, Scanlan CN, Wong CH, Moore JP, Olson WC, Ward AB, Poignard P, Schief WR, Burton DR, Wilson IA. A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield. Science 2011; 334:1097-103.

Diaz SL, Padler-Karavani V, Ghaderi D, Hurtado-Ziola N, Yu H, Brinkman-Van der Linden ECM, Varki A, Varki N.M. Sensitive and specific detection of the non-human sialic acid n-glycolylneuraminic acid in human tissues and biotherapeutic products. PLoS ONE. 2009; 4(1):e4241. Epub 2009 Jan 21.

Yue T, Goldstein IJ, Hollingsworth MA, Kaul K, Brand RE, Haab BB. The prevalence and nature of glycan alterations on specific proteins in pancreatic cancer patients revealed using antibody-lectin sandwich arrays. Mol Cell Proteomics. 2009; 8(7):1697-707. Epub 2009 Apr 17.

Kullolli M, Hancock WS, Hincapie M. Preparation of a high-performance multi-lectin affinity chromatography (HP-M-LAC) adsorbent for the analysis of human plasma glycoproteins. J Sep Sci. 2008; 14, 2733-9.

Ralin DW, Dultz SC, Silver JE, Kullolli M, Hancock WS, Hincapie M. Kinetic analysis of glycoprotein-lectin interactions by label free internal reflection. Exit Disclaimer Clin Proteomics. 2008;4,37-46.

Wang D, Wu A. Carbohydrate microarrays for lectin characterization and glyco-epitope identification. In: Nilsson, CL, ed. Lectins: Analytical Technologies. Elsevier; 2007.

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Glycans and Oncogenesis

Kudelka MR, Hinrichs BH, Darby T, Moreno CS, Nishio H, Cutler CE, Wang J, Wu H, Zeng J, Wang Y, Ju T, Stowell SR, Nusrat A, Jones RM, Neish AS, Cummings RD. Cosmc is an X-linked inflammatory bowel disease risk gene that spatially regulates gut microbiota and contributes to sex-specific risk. Proc Natl Acad Sci U S A 2016 Dec 20;113(51):14787-14792. doi: 10.1073/pnas.1612158114.

Mehta A, Comunale MA, Rawat S, Casciano JC, Lamontagne J, Herrera H, Ramanathan A, Betesh L, Wang M, Norton P, Steel LF, Bouchard MJ. Intrinsic hepatocyte dedifferentiation is accompanied by upregulation of mesenchymal markers, protein sialylation and core alpha 1,6 linked fucosylation. Sci Rep 2016 Jun 22;6:27965. doi: 10.1038/srep27965.

No publications on this topic were published during this year.

Radhakrishnan P, Dabelsteen S, Madsen FB, Francavilla C, Kopp KL, Steentoft C, Vakhrushev SY, Olsen JV, Hansen L, Bennett EP, Woetmann A, Yin G, Chen L, Song H, Bak M, Hlady RA, Peters SL, Opavsky R, Thode C, Qvortrup K, Schjoldager KT, Clausen H, Hollingsworth MA, Wandall HH. Immature truncated O-glycophenotype of cancer directly induces oncogenic features. Proc Natl Acad Sci U S A. 2014; 111(39):E4066-75.

Ju T, Aryal RP, Kudelka MR, Wang Y, Cummings RD. The Cosmc connection to the Tn antigen in cancer. Cancer Biomark. 2014; 14(1):63-81.

Mehta A, Norton P, Liang H, Comunale MA, Wang M, Rodemich-Betesh L, Koszycki A, Noda K, Miyoshi E, Block T. Increased levels of tetra-antennary N-linked glycan but not core fucosylation are associated with hepatocellular carcinoma tissue. Cancer Epidemiol Biomarkers Prev. 2012; 21(6):925-33.

Ju T, Wang Y, Aryal RP, Lehoux SD, Ding X, Kudelka MR, Cutler C, Zeng J, Wang J, Sun X, Heimburg-Molinaro J, Smith DF, Cummings RD. Tn and sialyl-Tn antigens, aberrant O-glycomics as human disease markers. Proteomics Clin Appl. 2013 Jul 16. [Epub ahead of print]

Lui NS, van Zante A, Rosen SD, Jablons DM, Lemjabbar-Alaoui H. SULF2 expression by immunohistochemistry and overall survival in oesophageal cancer: a cohort study. BMJ Open. 2012 Nov 23;2(6). doi:pii: e001624. 10.1136/bmjopen-2012-001624.

Guo H, Nairn A, Dela Rosa M, Nagy T, Zhao S, Moremen K, Pierce M. Transcriptional regulation of the protocadherin cluster during Her-2 protein-induced mammary tumorigenesis results from altered N-glycan branching. J Biol Chem. 2012; 287(30):24941-54.

Langer MD, Guo H, Shashikanth N, Pierce JM, Leckband DE. N-glycosylation alters cadherin-mediated intercellular binding kinetics. J Cell Sci. 2012; 125(Pt 10):2478-85.

Guo HB, Johnson H, Randolph M, Nagy T, Blalock R, Pierce M. Specific posttranslational modification regulates early events in mammary carcinoma formation. Proc Natl Acad Sci U. S. A. 2010; 107(49):21116-21

No publications on this topic were published during this year.

Abbott KL, Nairn AV, Hall EM, Horton MB, McDonald JF, Moremen KW, Dinulescu DM, Pierce M. Focused glycomic analysis of the N-linked glycan biosynthetic pathway in ovarian cancer. Proteomics. 2008; 8(16): p. 3210-20.

No publications on this topic were published during this year.

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Glycan Binding Proteins in Cancer

Lui NS, Yang YW, van Zante A, Buchanan P, Jablons DM, Lemjabbar-Alaoui H. SULF2 Expression Is a Potential Diagnostic and Prognostic Marker in Lung Cancer. PLoS One 2016 Feb 16;11(2):e0148911. eCollection 2016.

Singer MS, Phillips JJ, Lemjabbar-Alaoui H, Wang YQ, Wu J, Goldman R, Rosen SD. SULF2, a heparan sulfate endosulfatase, is present in the blood of healthy individuals and increases in cirrhosis. Clin Chim Acta. 2015; 440:72-8.

No publications on this topic were published during this year.

No publications on this topic were published during this year.

No publications on this topic were published during this year.

SIGLEC12, a Human-specific Segregating (Pseudo)gene, Encodes a Signaling Molecule Expressed in Prostate Carcinomas. Mitra N, Banda K, Altheide TK, Schaffer L, Johnson-Pais TL, Beuten J, Leach RJ, Angata T, Varki N, Varki A. J Biol Chem. 2011; 286:23003-11.

No publications on this topic were published during this year.

Thomas E, Newsom-Davis TE, Wang D, Steinman L, Chen PFT, Wang L, Simon AK, Screaton, GR. Enhanced immune recognition of cryptic glycan markers in human tumors. Cancer Res. 2009;69 (5):2018-2025.

Costa NR, Mendes N, Marcos NT, Reis CA, Caffrey T, Hollingsworth MA, Santos-Silva F. Relevance of MUC1 mucin variable number of tandem repeats polymorphism in H pylori adhesion to gastric epithelial cells. World J Gastroenterol. 2008;14(9):1411-4.

Hedlund M, Padler-Karavani V, Varki N, Varki A. Evidence for a human-specific mechanism for diet and antibody-mediated inflammation in carcinoma progression. Proc Natl Acad Sci. 2008;105:18936-18941.

Padler-Karavani V, Yu H, Cao H, Chokhawala H, Karp F, Varki N, Chen X, Varki A. Diversity in specificity, abundance and composition of anti-neu5Gc antibodies in normal humans: potential implications for disease. Glycobiology. 2008;18:818-830.

Swanson BJ, McDermott KM, Singh PK, Eggers JP, Crocker PR, Hollingsworth MA. MUC1 is a counter-receptor for myelin-associated glycoprotein (siglec-4a) and their interaction contributes to adhesion in pancreatic cancer perineural invasion. Cancer Res. 2007;67(21):10222-9.

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Reviews

Lemjabbar-Alaoui H, Hassan OU, Yang YW, Buchanan P. Lung cancer: Biology and treatment options. Biochim Biophys Acta 2015 Dec;1856(2):189-210. Review.

Tang H, Hsueh P, Kletter D, Bern M, Haab B. The detection and discovery of glycan motifs in biological samples using lectins and antibodies: new methods and opportunities. Adv Cancer Res 2015;126:167-202. Review.

Kudelka MR, Ju T, Heimburg-Molinaro J, Cummings RD. Simple sugars to complex disease-mucin-type o-glycans in cancer. Adv Cancer Res. 2015; 126:53-135.

Tang H, Hsueh P, Kletter D, Bern M, Haab B. The detection and discovery of glycan motifs in biological samples using lectins and antibodies: new methods and opportunities. Adv Cancer Res. 2015; 126:167-202.

Mehta A, Herrera H, Block T. Glycosylation and liver cancer. Adv Cancer Res. 2015; 126:257-79.

Guo H, Abbott KL. Functional impact of tumor-specific N-linked glycan changes in breast and ovarian cancers. Adv Cancer Res. 2015; 126:281-303.

Lemjabbar-Alaoui H, McKinney A, Yang YW, Tran VM, Phillips JJ. Glycosylation alterations in lung and brain cancer. Adv Cancer Res. 2015; 126:305-44.

Cummings RD, Pierce JM. The challenge and promise of glycomics. Chem Biol. 2014; 21(1):1-15.

Palma AS, Feizi T, Childs RA, Chai W, Liu Y. The neoglycolipid (NGL)-based oligosaccharide microarray system poised to decipher the meta-glycome. Curr Opin Chem Biol. 2014; 18:87-94.

Wang D Glyco-epitope Diversity: An Evolving Area of Glycomics Research and Biomarker Discovery J Proteomics Bioinform. 2014 7:2.

Haab BB, Partyka K, Cao Z. Using antibody arrays to measure protein abundance and glycosylation: considerations for optimal performance. Curr Protoc Protein Sci. 2013; 73:Unit 27.6. doi: 10.1002/0471140864.ps2706s73.

Chandler KB, Goldman R. Glycoprotein disease markers and single protein-omics. Mol Cell Proteomics. 2013; 12:836-45.

Wade A, Robinson AE, Engler JR, Petritsch C, David James C, Phillips JJ. Proteoglycans and their roles in brain cancer. FEBS J. 2013; 280(10):2399-417.

No reviews were published during this year.

Padler-Karavani V, Varki A. Potential impact of the non-human sialic acid N-Glycolylneuraminic acid on transplant rejection risk. Xenotransplantation (Invited Commentary), 2011; 18:1-5.

Wang D. (2011). Carbohydrate Antigen Microarrays. In: ed. Chevolot Y. Carbohydrate Microarrays, Microarray Methods & Protocols, Humana Press, 2011; pp. 241-249.

Carroll GT, Wang D. Photoimmobilization of Saccharides, In: ed. Chevolot Y. Carbohydrate Microarrays, Microarray Methods & Protocols, Humana Press, 2011; (in press).

Tousi F, Hancock WS, Hincapie, M.? Technologies and strategies for glycoproteomics and glycomics and their application to clinical biomarker research. Anal Methods. 2011; 3(1):20?32.

Chen X, Varki A. Advances in the biology and chemistry of sialic acids. ACS Chem Biol. 2010;5(2):163-76.

Taylor AD, Hancock WS, Hincapie M, Taniguchi N, Hanash SM. Towards an integrated proteomic and glycomic approach to finding cancer biomarkers. Genome Med. 2009;1(6):57.

Wang D. Carbohydrate arrays. In: Matson, RS, ed. Microarray Methods & Protocols. 2008;CRC Press.

Liu Y, Palma AS , Feizi T. Carbohydrate microarrays: key developments in glycobiology. Biol Chem 2009;390:647-656.

Zhou X, Carroll GT, Turchi C, Wang D. Carbohydrate microarrays as essential tools of postgenomic medicine, In: Garg HG, Cowman MK, Hales CA, ed. Carbohydrate chemistry and biology for physicians. Elsevier, 2008.

No reviews were published during this year.

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Last updated: 13 March 2017